6-QUINOXALINECARBOXYLIC ACID synthesis
- Product Name:6-QUINOXALINECARBOXYLIC ACID
- CAS Number:6925-00-4
- Molecular formula:C9H6N2O2
- Molecular Weight:174.16
23088-23-5
100 suppliers
$12.00/250mg
6925-00-4
169 suppliers
$23.00/1 g
Yield:6925-00-4 76.6%
Reaction Conditions:
Stage #1:methyl quinoxaline-6-carboxylate with sodium hydroxide in ethanol;water for 4 h;Heating / reflux;
Stage #2: with hydrogenchloride in ethanol;water; pH=4
Steps:
I.1
Preparation Example I-1. Quinoxaline-6-carboxylic acid To a solution of quinoxaline-6-carboxylic acid methyl ester (2084mg, 11.07mmol) in ethanol (25mL) was added an aqueous solution of 1 N sodium hydroxide (25mL), and the solution was stirred for 4 hours under reflux. 1 N Hydrochloric acid was added to the reaction mixture to adjust the pH to 4, then, the precipitated solid was collected by filtration, washed with water and isopropanol, then dried to obtain the title compound (1477mg, 8.479mmol, 76.6%) as a solid. 1H-NMR Spectrum (DMSO-d6) δ (ppm): 8.18 (1 H, d, J=8.4Hz), 8.29 (1H, dd, J=8.4, 1.2Hz), 8.61 (1 H, d, J=1.2Hz), 9.00-9.07 (2H, m).
References:
Eisai R&D Management Co., Ltd. EP1782811, 2007, A1 Location in patent:Page/Page column 59
141-43-5
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619-05-6
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$18.00/5g
6925-00-4
169 suppliers
$23.00/1 g
107-83-5
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$10.00/1g
23088-23-5
100 suppliers
$12.00/250mg
6925-00-4
169 suppliers
$23.00/1 g
258503-93-4
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$44.00/100mg
517-21-5
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$17.00/25g
619-05-6
299 suppliers
$18.00/5g
6925-00-4
169 suppliers
$23.00/1 g