ChemicalBook CAS DataBase List 6-BROMO-2-METHYL-1,3-BENZOTHIAZOLE

6-BROMO-2-METHYL-1,3-BENZOTHIAZOLE synthesis

10synthesis methods

Product Name:6-BROMO-2-METHYL-1,3-BENZOTHIAZOLE
CAS Number:5304-21-2
Molecular formula:C8H6BrNS
Molecular Weight:228.11

562080-91-5

5304-21-2

General procedure for the synthesis of 6-bromo-2-methyl-1,3-benzothiazole from N-(4-bromo-2-iodophenyl)acetamide: N-(4-bromo-2-iodophenyl)acetamide (678 mg, 2.00 mmol) was dissolved in N,N-dimethylformamide (4.00 mL), followed by the addition of sodium sulfide nonahydrate (721 mg, 6.00 mmol) and copper iodide (I) (38.0 mg, 0.200 mmol). The reaction mixture was stirred at 80 °C. After the reaction was completed, it was cooled to room temperature, concentrated hydrochloric acid (1.6 mL) was added, and stirring was continued at 80 °C for 12 hours. At the end of the reaction, saturated aqueous sodium bicarbonate solution (20 mL) was added to neutralize. Extraction was performed with ethyl acetate (50 mL x 2). The organic layers were combined, washed with saturated aqueous sodium chloride solution and dried over anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure and the residue was purified by silica gel column chromatography to afford 6-bromo-2-methyl-1,3-benzothiazole (134 mg, 29.5% yield) using hexane/ethyl acetate (4:1, v/v) as eluent.

562080-91-5
35 suppliers
$251.68/250mg

5304-21-2
112 suppliers
$14.00/250mg

Yield:5304-21-2 29.5%

Reaction Conditions:

Stage #1:N-(4-bromo-2-iodophenyl)acetamide with copper(l) iodide;sodiumsulfide nonahydrate in N,N-dimethyl-formamide at 80; for 8 h;
Stage #2: with hydrogenchloride in water;N,N-dimethyl-formamide at 80; for 12 h;

Steps:

5 Synthesis of 6-bromo-2-methyl-benzothiazole (Compound 11)
Compound 10 (678 mg, 2.00 mmol)Was dissolved in dimethylformamide (4.00 mL)Sodium sulfide nonahydrate (721 mg, 6.00 mmol),Copper (I) iodide (38.0 mg, 0.200 mmol) was added,And the mixture was stirred at 80 ° C. for 8 hours.After returning to room temperature,Concentrated hydrochloric acid (1.6 mL) was added,And the mixture was further stirred at 80 ° C. for 12 hours.Saturated aqueous sodium hydrogen carbonate solution (20 mL) was added,And extracted with ethyl acetate (50 mL × 2).The organic layer was washed with saturated brine,After dehydration with anhydrous magnesium sulfate,The solvent was distilled off under reduced pressure,The residue was subjected to silica gel column chromatography using ethyl acetate / hexane (1/4 (volume ratio)) as an elution solvent,Compound 11 was obtained in a yield of 134 mg (29.5%).

References:

Kyoto University;Nihon Medi-Physics Co.,Ltd.;Saji, Hideo;Ono, Masahiro;Inohara, Tadashi;Seki, Ikuya JP2016/79108, 2016, A Location in patent:Paragraph 0055

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