Ethyl 3-(((benzyloxy)carbonyl)-(2-ethoxy-2-oxoethyl)amino)propanoate synthesis
- Product Name:Ethyl 3-(((benzyloxy)carbonyl)-(2-ethoxy-2-oxoethyl)amino)propanoate
- CAS Number:51814-17-6
- Molecular formula:C17H23NO6
- Molecular Weight:337.37
3783-61-7
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501-53-1
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51814-17-6
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$181.25/1g
Yield:51814-17-6 98%
Reaction Conditions:
with triethylamine in toluene at 0 - 30; for 6 h;Reagent/catalyst;Temperature;
Steps:
2.A; 2.B A: Preparation of CBZ protected compound
To a solution of 40 g (0.1968 moles) of protected glycine ester and 27.84 g (0.2751 moles) of triethyl amine in 320 mL of toluene was charged 40.17 g (0.2355 moles) of benzyl chloroformate at 0-5 ° C. The resultant reaction mixture was heated to 25-30 ° C and stirred for 6 hrs at 25-30 ° C. Upon completion of the reaction, the reaction mixture was quenched with 200 mL of 1 N HCl, followed by 200 mL of water wash. The organic layers were distilled off completely and swapped with toluene (80 ml) to get CBZ protected compound. Yield: 98%
References:
WO2022/44037,2022,A1 Location in patent:Page/Page column 6-7
623-33-6
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501-53-1
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140-88-5
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51814-17-6
16 suppliers
$181.25/1g
623-33-6
657 suppliers
$5.00/10g
501-53-1
414 suppliers
$10.00/1g
51814-17-6
16 suppliers
$181.25/1g
140-88-5
550 suppliers
$12.00/100ml
51814-17-6
16 suppliers
$181.25/1g
539-74-2
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51814-17-6
16 suppliers
$181.25/1g