5-IODO-6-METHYLPYRIMIDIN-4-OL synthesis
- Product Name:5-IODO-6-METHYLPYRIMIDIN-4-OL
- CAS Number:7752-74-1
- Molecular formula:C5H5IN2O
- Molecular Weight:236.01
3524-87-6
185 suppliers
$29.00/1g
7752-74-1
44 suppliers
$23.00/100mg
Yield:-
Reaction Conditions:
with N-iodo-succinimide;acetic acid at 20; for 30 h;
Steps:
A-2
To 70 g (0.64 mol) A-l in acetic acid is added 127 g (0.56 mol) NIS portion wise at RT within 15 min. The reaction is stirred at RT until all starting material is consumed (30 h). The reaction mixture is diluted with water and the solid product is filtered off, washed with an aqueous sodium thiosulfate solution to remove excess iodine and dried in vacuo. Yield: 90 g (60 %).
References:
WO2012/101184,2012,A1 Location in patent:Page/Page column 50
3524-87-6
185 suppliers
$29.00/1g
7752-74-1
44 suppliers
$23.00/100mg
56-04-2
379 suppliers
$5.00/100mg
7752-74-1
44 suppliers
$23.00/100mg