(5-Carboxypentyl)(triphenyl)phosphonium bromide synthesis
- Product Name:(5-Carboxypentyl)(triphenyl)phosphonium bromide
- CAS Number:50889-29-7
- Molecular formula:C24H26BrO2P
- Molecular Weight:457.34
4224-70-8
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50889-29-7
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Yield:50889-29-7 100%
Reaction Conditions:
with triphenylphosphine in toluene at 120; for 17 h;
Steps:
5.1 4.5.1 (6-Carboxyhexyl)triphenylphosphonium bromide (11)
In a 100?mL triple-necked round-bottom flask 5.01?g (19.1?mmol, 1.0 eq.) 6-bromohexanoic acid and 6.71?g (19.61 mmol, 1.0 eq.) triphenylphosphine were dissolved in 30?mL dry toluene. The reaction mixture was heated to 120? °C and stirred for 17?h. After cooling to room temperature, the product was collected by filtration and washed with toluene (2?*?20?mL) and Et2O (2?*?20?mL) before drying under reduced pressure. 11 was obtained as colorless powder in quantitative yield. m.p.?=?201-205?°C; 1H NMR (300.36?MHz; CDCl3) δ?=?9.12 (s, 1H), 7.74 (m, 15H), 3.60 (s, 2H), 2.34 (s, 2H), 1.64 (s, 6H); 13C NMR (75.53?MHz; CDCl3) δ?=?175.9, 135.1, 133.7, 133.6, 130.7, 130.5, 34.27, 29.6, 24.0, 21.9, 22.2.
References:
Migglautsch, Anna K.;Willim, Melissa;Schweda, Bettina;Glieder, Anton;Breinbauer, Rolf;Winkler, Margit [Tetrahedron,2018,vol. 74,# 43,p. 6199 - 6204]
502-44-3
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6399-81-1
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50889-29-7
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1191-25-9
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50889-29-7
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60633-18-3
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50889-29-7
226 suppliers
$5.00/1g