5-BROMO-2,2'-BIPYRIDINE synthesis
- Product Name:5-BROMO-2,2'-BIPYRIDINE
- CAS Number:15862-19-8
- Molecular formula:C10H7BrN2
- Molecular Weight:235.08
624-28-2
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13737-05-8
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15862-19-8
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$20.00/100mg
Yield:15862-19-8 63%
Reaction Conditions:
with tetrakis(triphenylphosphine) palladium(0) in 5,5-dimethyl-1,3-cyclohexadiene; for 15 h;Reflux;
Steps:
5-Bromo-2,2’-bipyridine
1.91 g (7.89 mmol, 1.0 eq) 2-(trimethylstannyl)pyridine and 2.08 g (8.77 mmol, 1.1 eq), 2,5-dibromopyridine are dissolved in 16 mL freshly distilled xylene. The degassed solution is treated with0.061 g (0.053 mmol, 0.06 eq) Pd(PPh3)4 and stirred under reflux for 15 hours. After addition of 40 mL2N NaOH, the mixture is extracted with 40 mL toluene (3x). The organic phase is washed with brine,dried over MgSO4 and the solvent is removed in vacuo. Purification via column chromatography (SiO2,3.5 x 10 cm, pentane/EtOAc = 20/1 10/1) yields 2.57 g (63%) 5-bromo-2,2’-bipyridine as colourlesssolid.
References:
B?hm, Alexander;Bach, Thorsten [Synlett,2016,vol. 27,# 7,p. 1056 - 1060] Location in patent:supporting information
624-28-2
730 suppliers
$5.00/5g
17997-47-6
176 suppliers
$18.00/1g
15862-19-8
145 suppliers
$20.00/100mg
109-04-6
540 suppliers
$6.00/25g
223463-13-6
388 suppliers
$5.00/1g
15862-19-8
145 suppliers
$20.00/100mg
366-18-7
662 suppliers
$5.00/5g
15862-19-8
145 suppliers
$20.00/100mg
223463-13-6
388 suppliers
$5.00/1g
17997-47-6
176 suppliers
$18.00/1g
15862-19-8
145 suppliers
$20.00/100mg