5,8-Dibromoquinoline synthesis
- Product Name:5,8-Dibromoquinoline
- CAS Number:81278-86-6
- Molecular formula:C9H5Br2N
- Molecular Weight:286.95
3638-73-1
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81278-86-6
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Yield: 90%
Reaction Conditions:
with sulfuric acid;iodine;iron(II) sulfate at 138; for 4 h;Temperature;Concentration;
Steps:
3.3
To the reaction flask was added 2.0 g of 2,5-dibromobenzene, 0.19 g of iodine, 0.17 g of ferrous sulfate, glycerol1.76 ml (dibromoaniline molar amount: glycerol mole = 1: 6), concentrated sulfuric acid44 ml (V glycerol: VConcentrated sulfuric acid = 1:25) and stirred at 138 ° C for 4 hours. After the completion of the reaction, the pH of the reaction solution was adjusted to 7.0 with lye. Ethyl acetate was extracted, dried and concentrated. The resulting crude product was purified by silica gel column eluting with a mixture of ethyl acetate and petroleum ether (V ethyl acetate: V petroleum ether = 1:19)Yield 90%.
References:
Nanjing Tech University;Yang, Wenge;Zhang, Tuan;Hu, Yonghong;Wu, Keyi;Wang, Kai;Wang, Chaoyuan;Li, Yihua CN103923102, 2017, B Location in patent:Paragraph 0036; 0041; 0046
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1000210-73-0
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81278-86-6
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16567-18-3
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4964-71-0
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81278-86-6
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