4-hydroxy-5-methoxy-2-pyridinecarboxylic acid synthesis
- Product Name:4-hydroxy-5-methoxy-2-pyridinecarboxylic acid
- CAS Number:51727-04-9
- Molecular formula:C7H7NO4
- Molecular Weight:169.13
62885-42-1
14 suppliers
$133.00/5G
51727-04-9
15 suppliers
$211.46/250mg
Yield:51727-04-9 2.9 g
Reaction Conditions:
with nitric acid at 20; for 1 h;
Steps:
4-hydroxy-5-methoxypyrid ine-2-carboxylic acid
Concentrated nitric acid (25 mL, c = 65 %) and fuming nitric acid (5.0 mL, c = 90 %) were added to 2-(hydroxymethyl)-5-methoxypyridin-4-ol (4.97 g, 32.0 mmcl) . The mixture was stirred at r.t. for I day, then poured into icewater. The precipitate was collected by filtration and the dissolved in diluted sodium hydroxide solution. Hydrochloric acid (c = 2N) was added untilpH4 was reached. A solid precipitated and was collected by filtration to give 2.90 g of the title compound.LC-MS (Method 5): R 0.17 mm; MS (ESIpos): m/z = 170 [M+H]
References:
WO2017/102091,2017,A1 Location in patent:Page/Page column 343
501-30-4
664 suppliers
$5.00/25mg
51727-04-9
15 suppliers
$211.46/250mg
6269-25-6
45 suppliers
$244.00/500mg
51727-04-9
15 suppliers
$211.46/250mg