(4-Fluorophenoxy)acetaldehyde Diethyl Acetal synthesis
- Product Name:(4-Fluorophenoxy)acetaldehyde Diethyl Acetal
- CAS Number:59769-37-8
- Molecular formula:C12H17FO3
- Molecular Weight:228.26
371-41-5
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2032-35-1
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59769-37-8
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Yield:59769-37-8 97%
Reaction Conditions:
with potassium hydroxide in N,N-dimethyl acetamide at 20;Heating;
Steps:
Preparation of 2-aryloxyacetaldehyde diethyl acetals 1a-1t
General procedure: A 250 mL round-bottomed flask was charged with phenol 3 (50 mmol), DMAC (100 mL) and KOH(6.6 g, 100 mmol), followed by adding dropwise with 2-bromoacetaldehyde diethyl acetal (15.1 g, 75mmol) at room temperature. After the addition, the mixture was stirred under refluxing for 2-3 hoursuntil the reaction was completed based on GC determination. Then the mixture was cool to roomtemperature and extracted with ether (100 mL x 3). The combined organic layers were subsequentlywashed with 5% NaOH aqueous solution and water, dried over anhydrous MgSO4, filtered off andremoved solvent to dryness in vacuo. The residual was finally purified by flash columnchromatography on SiO2 (petroleum ether/ethyl acetate) to afford the desired 2-aryloxyacetaldehydediethyl acetals.
References:
Sun, Nan;Huang, Peng;Wang, Yifan;Mo, Weimin;Hu, Baoxiang;Shen, Zhenlu;Hu, Xinquan [Tetrahedron,2015,vol. 71,# 29,p. 4835 - 4841] Location in patent:supporting information
371-41-5
530 suppliers
$8.00/25g
59769-37-8
15 suppliers
$195.00/1g
371-41-5
530 suppliers
$8.00/25g
621-62-5
224 suppliers
$6.00/25g
59769-37-8
15 suppliers
$195.00/1g