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ChemicalBook CAS DataBase List 4-(BROMOMETHYL)-8-FLUOROQUINOLIN-2(1H)-ONE
176912-29-1

4-(BROMOMETHYL)-8-FLUOROQUINOLIN-2(1H)-ONE synthesis

3synthesis methods
-

Yield:176912-29-1 65%

Reaction Conditions:

with sulfuric acid at 45; for 18 h;Inert atmosphere;

References:

Bonnefous, Céline;Payne, Joseph E.;Roppe, Jeffrey;Zhuang, Hui;Chen, Xiaohong;Symons, Kent T.;Nguyen, Phan M.;Sablad, Marciano;Rozenkrants, Natasha;Zhang, Yan;Wang, Li;Severance, Daniel;Walsh, John P.;Yazdani, Nahid;Shiau, Andrew K.;Noble, Stewart A.;Rix, Peter;Rao, Tadimeti S.;Hassig, Christian A.;Smith, Nicholas D. [Journal of Medicinal Chemistry,2009,vol. 52,# 9,p. 3047 - 3062] Location in patent:experimental part Payne, Joseph E.;Bonnefous, Céline;Symons, Kent T.;Nguyen, Phan M.;Sablad, Marciano;Rozenkrants, Natasha;Zhang, Yan;Wang, Li;Yazdani, Nahid;Shiau, Andrew K.;Noble, Stewart A.;Rix, Peter;Rao, Tadimeti S.;Hassig, Christian A.;Smith, Nicholas D. [Journal of Medicinal Chemistry,2010,vol. 53,# 21,p. 7739 - 7755] Location in patent:experimental part