ChemicalBook CAS DataBase List 4-Amino-3-chlorobenzotrifluoride

4-Amino-3-chlorobenzotrifluoride synthesis

10synthesis methods

Product Name:4-Amino-3-chlorobenzotrifluoride
CAS Number:39885-50-2
Molecular formula:C7H5ClF3N
Molecular Weight:195.57

328-84-7

39885-50-2

121-50-6

The general procedure for the synthesis of 3-chloro-4-aminobenzotrifluoride and 3-amino-4-chlorobenzotrifluoride from 3,4-dichlorobenzotrifluoride was as follows: 1. 1050 mL of N-methylpyrrolidone and 102 g of anhydrous activated potassium fluoride were added to an autoclave followed by 377 g of 3,4-dichlorobenzotrifluoride. 2. 158 g of ammonia was vented from a pressure tank into the reactor at ambient temperature. 3. the reaction mixture was heated to 245-250°C over a period of 2 hours, at which time the reactor pressure reached 30-32 kg/cm2 . 4. continued to add excess ammonia from the pressure tank to maintain reactor pressure of 38-40 kg/cm2 at 245-250°C liquid temperature. 5. maintain the reaction mixture at 245-250°C and 38-40 kg/cm2 pressure for 8 hours. 6. cool the reaction mixture to ambient temperature, vent and recover unreacted ammonia. 7. Filter the reaction mixture and separate the products by fractional distillation. Based on the consumed 3,4-dichlorobenzotrifluoride, 3-chloro-4-aminobenzotrifluoride in 77% yield and 3-amino-4-chlorobenzotrifluoride in 13% yield were obtained.

1-[2-CHLORO-4-(TRIFLUOROMETHYL)PHENYL]HYDRAZINE

86398-98-3
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39885-50-2
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Yield:39885-50-2 100%

Steps:

2 EXAMPLE 2 Preparation of 2-Chloro-4-Trifluoromethylaniline

The procedure of Example 1 was repeated but using 2-chloro-4-trifluoromethylphenylhydrazine, to give the title compound in 100% yield.

References:

US6410737,2002,B1 Location in patent:Page column 6

328-84-7 Synthesis

328-84-7
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39885-50-2
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121-50-6 Synthesis

121-50-6
345 suppliers
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References