4,6-DICHLORO-2-ETHYL-5-PYRIMIDINAMINE synthesis
- Product Name:4,6-DICHLORO-2-ETHYL-5-PYRIMIDINAMINE
- CAS Number:6237-96-3
- Molecular formula:C6H7Cl2N3
- Molecular Weight:192.05
6237-95-2
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Yield:-
Reaction Conditions:
aluminum nickel in methanol;
Steps:
127 5-Amino-4,6-dichloro-2-ethylpyrimidine
EXAMPLE 127 5-Amino-4,6-dichloro-2-ethylpyrimidine 4,6-Dichloro-5-nitro-2-ethylpyrimidine (185 g, 0.83 mol) was dissolved in methanol (1.5 L) and reduced under 15 p.s.i. H2 in the presence of Raney nickel (30 g) for 5 hr. The mixture was filtered through Celite (washing well with MeOH) and the filtrate was evaporated to dryness to give 159.1 g (0.83 mol, quantitative yield) of the title compound as a chromatographically pure (silica gel plates, developed with EtOAc:hexanes, 3:1) dark liquid which was used directly in the next step.
References:
US5057517,1991,A