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ChemicalBook CAS DataBase List 4,5,6-TRIAMINOPYRIMIDINE
118-70-7

4,5,6-TRIAMINOPYRIMIDINE synthesis

11synthesis methods
4,6-Pyrimidinediamine, 5-nitroso- (9CI)

61908-15-4

4,5,6-TRIAMINOPYRIMIDINE

118-70-7

Step 4: Wetted 4,6-diamino-5-nitrosopyrimidine was loaded into a reaction column. 400 mL of methanol and 4 g of 5% palladium carbon catalyst were added to the autoclave and the reaction was stirred at room temperature in a hydrogen atmosphere. Upon completion of the reaction, methanol was removed by evaporating the filtrate. The resulting 4,5,6-triaminopyrimidine can be used directly in the subsequent reaction steps without further purification in 95% yield.

-

Yield: 93%

Reaction Conditions:

with hydrazine hydrate in ethanol at 25;Temperature;

Steps:

1.3-4.3
0022; 0025; 0027; 0030; 0032; 0035; 0037; 0040

References:

Nanjing Puruida Pharmaceutical Technology Co., Ltd.;Wang Xiaobo CN110407757, 2019, A Location in patent:Paragraph 0022; 0026-0027; 0031-0032; 0036-0037; 0041

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