methyl 2-(4-chlorophenyl)-1,3-oxazole-4-carboxylate synthesis
- Product Name:methyl 2-(4-chlorophenyl)-1,3-oxazole-4-carboxylate
- CAS Number:300800-07-1
- Molecular formula:C11H8ClNO3
- Molecular Weight:237.64
Yield:300800-07-1 76%
Reaction Conditions:
Stage #1: methyl (2S)-2-amino-3-hydroxypropanoate hydrochloride;4-chlorobenzaldehydewith magnesium sulfate;triethylamine in tetrahydrofuran at 20; for 12 h;
Stage #2: with Bromotrichloromethane;1,8-diazabicyclo[5.4.0]undec-7-ene in dichloromethane at 0 - 20; for 12 h;
References:
Graham, Thomas H. [Organic Letters,2010,vol. 12,# 16,p. 3614 - 3617] Location in patent:supporting information; experimental part
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