3-Pyridineethaneamine synthesis
- Product Name:3-Pyridineethaneamine
- CAS Number:20173-24-4
- Molecular formula:C7H10N2
- Molecular Weight:122.17
6443-85-2
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20173-24-4
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$8.00/250mg
Yield:20173-24-4 45%
Reaction Conditions:
with ammonium hydroxide;hydrogen in methanol at 20; under 760.051 Torr;
Steps:
63.1 Step 1: Synthesis of 2-(pyridin-3-yl)ethanamine
A mixture of 2-(pyridin-3-yl)acetonitrile (1 g, 8.47 mmol, 1.00 equiv), Raney nickel (1 g, 17.24 mmol, 1.00 equiv) and ammonium hydroxide (3 mL) in methanol (15 mL) was stirred under 1 atmosphere of hydrogen at room temperature overnight. The catalyst was removed by filtration through a pad of Celite and washed with several portions of methanol. The filtrate and washings were combined and concentrated under vacuum to give 940 mg (45%) of 2-(pyridin-3-yl)ethanamine as a yellow oil. LC-MS: (ES, m/z): 164 [M+CH3CN+H]+, 123 [M+H]+, 106.
References:
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY;AUCKLAND UNISERVICES LIMITED;RUGA CORPORATION;GIACCA, Amato;LAI, Edwin;RAZORENOVA, Olga;CHAN, Denise;HAY, Michael, Patrick;BONNET, Muriel;SUN, Connie;TABIBIAZAR, Ray;YUEN, Po-wai WO2013/155338, 2013, A2 Location in patent:Page/Page column 180
92639-84-4
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20173-24-4
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350-03-8
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92990-44-8
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20173-24-4
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6283-81-4
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20173-24-4
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