3-ETHOXYACRYLIC ACID synthesis
- Product Name:3-ETHOXYACRYLIC ACID
- CAS Number:6192-01-4
- Molecular formula:C5H8O3
- Molecular Weight:116.12
5941-55-9
6192-01-4
General procedure: ethyl (E)-3-ethoxyacrylate (5.0 g, 0.035 mol) was dissolved in 2 M aqueous sodium hydroxide solution (40 mL) and the reaction was refluxed for 4 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the pH was adjusted to 3 with 4 M aqueous hydrochloric acid, followed by extraction with ethyl acetate. The organic phase was decolorized by activated carbon and dried over anhydrous sodium sulfate, then filtered and concentrated to dryness under reduced pressure to afford 3-ethoxyacrylic acid as a brown solid (1.8 g, 44% yield).
122-51-0
512 suppliers
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6192-01-4
128 suppliers
$12.00/1g
Yield:6192-01-4 79%
Reaction Conditions:
with acetic anhydride
Steps:
Synthesis of ethyl 2-(2,3,4,5-tertrafluorobenzoyl)-3-ethoxyacrylate, Compound j.
Synthesis of ethyl 2-(2,3,4,5-tertrafluorobenzoyl)-3-ethoxyacrylate, Compound j. A mixture of compound i (22 g, 83 mmol), triethyl orthoformate (17 g, 115 mmol), and 20 g of acetic anhydride was heated at 150° C. with stirring for 2 hours. Removal of the solvent in vacuo gave the crude product for next step, yield 79%.
References:
Zhi, Chengxin;Wright, George E. US2003/181719, 2003, A1
1001-26-9
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6192-01-4
128 suppliers
$12.00/1g
61310-53-0
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$41.00/25mL
6192-01-4
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$12.00/1g
6191-99-7
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$24.00/1g
6192-01-4
128 suppliers
$12.00/1g
10601-80-6
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$6.00/5g
6192-01-4
128 suppliers
$12.00/1g