(3-(4-bromophenyl)oxetan-3-yl)methanol synthesis
- Product Name:(3-(4-bromophenyl)oxetan-3-yl)methanol
- CAS Number:1188264-15-4
- Molecular formula:C10H11BrO2
- Molecular Weight:243.1
![Oxetane, 3-(4-bromophenyl)-3-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-](/CAS/20210305/GIF/1620017-14-2.gif)
1620017-14-2
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1188264-15-4
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Yield:1188264-15-4 47%
Reaction Conditions:
with tetrabutyl ammonium fluoride in tetrahydrofuran at 20; for 2 h;
Steps:
(3-Methoxyoxetan-3-yl)methanol (5)
General procedure: A 1M solution of TBAF in THF (6.73 mL, 6.73 mmol) was added to tert-butyl[(3-methoxyoxetan-3-yl)methoxy]diphenylsilane (2.4 g,6.73 mmol) in THF (20 mL) at ambient temperature. The resulting solution was stirred for 2 h. The reaction mixture was evaporated to dryness to give a crude product, which was purified by flash silica gel chromatography, eluted with a gradient of 0 to 100% EtOAc in heptane. Pure fractions were evaporated to dryness to afford(3-methoxyoxetan-3-yl)methanol (0.650 g, 82%) as a colourless oil.
References:
Boyd, Scott;Davies, Christopher D. [Tetrahedron Letters,2014,vol. 55,# 30,p. 4117 - 4119] Location in patent:supporting information
936494-74-5
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1188264-15-4
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