3-(3-IODO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER synthesis
- Product Name:3-(3-IODO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER
- CAS Number:68332-33-2
- Molecular formula:C11H11IO3
- Molecular Weight:318.11
58313-23-8
144 suppliers
$7.00/5g
141-78-6
654 suppliers
$24.69/250ml
68332-33-2
24 suppliers
$59.39/1g
Yield:68332-33-2 100%
Reaction Conditions:
with potassium tert-butylate in tetrahydrofuran at 0 - 20; for 2.25 h;
Steps:
23.23A
Ethyl-3-iodobenzoate (25.4 g, 92.0 mmol) was dissolved in THF (60 mL) and cooled to 0° C. followed by the addition of KOt-Bu (20.6 g, 184 mmol). The mixture was stirred for 15 minutes followed by the addition of ethyl acetate (8.91 g, 101 mmol). The mixture was warmed to ambient temperature, stirred for 2 hours, diluted with aqueous HCl (10%, 200 mL) and extracted with ethyl acetate (2 150 mL). The combined organic layers were dried (Na 2SO 4), filtered and concentrated in vacuo to provide the titled compound (29.3 g, 100%).
References:
US2004/214870,2004,A1 Location in patent:Page 27
14452-30-3
134 suppliers
$8.00/1g
105-58-8
471 suppliers
$17.00/25g
68332-33-2
24 suppliers
$59.39/1g
58313-23-8
144 suppliers
$7.00/5g
68332-33-2
24 suppliers
$59.39/1g
