Carbamimidothioicacid, (4-methoxyphenyl)methyl ester, hydrochloride (1:1) synthesis
- Product Name:Carbamimidothioicacid, (4-methoxyphenyl)methyl ester, hydrochloride (1:1)
- CAS Number:25985-08-4
- Molecular formula:C9H13ClN2OS
- Molecular Weight:232.7303
824-94-2
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Yield:25985-08-4 96%
Reaction Conditions:
with thiourea in tetrahydrofuran;
Steps:
a Dihydropyrimidine Intermediates
a. 2-(4-METHOXYBENZYL)-2-THIOPSEUDOUREA HYDROCHLORIDE. Into a well-stirred suspension of thiourea (7.6 g, 0.1 mol) in THF (50 mL) at 0° C., 4-methoxybenzyl chloride (16 g, 0.1 mol) was added in 10 min and the reaction mixture was allowed to warm to room temperature. After 2 hours the reaction mixture was heated to 65° C. and kept at that temperature for 5 hours. The reaction mixture was cooled to room temperature and diluted with diethyl ether (200 mL). The white precipitate that formed was filtered and dried (22.5 g, 96% yield); m. p. 161-163° C.
References:
US2003/69261,2003,A1
2746-25-0
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17356-08-0
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25985-08-4
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105-13-5
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