ChemicalBook CAS DataBase List (3S,5R,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid

(3S,5R,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid synthesis

5synthesis methods

Product Name:(3S,5R,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid
CAS Number:254452-86-3
Molecular formula:C25H24FNO4
Molecular Weight:421.46

2-Cyclopropyl-4-(4-fluorophenyl)-quinolyl-3-methanol

121660-11-5
238 suppliers
$6.00/100mg

(3S,5R,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid

254452-86-3
15 suppliers
inquiry

Yield:-

Steps:

Multi-step reaction with 6 steps
1.1: DMSO; P₂O₅; Et₃N
2.1: NaOH; (n-octyl)3MeNCl / toluene; H₂O
3.1: DIBAH
4.1: NaH; n-BuLi
5.1: NaBH₄; Et₂BOMe / -78 °C
6.1: aq. NaOH
6.2: (-)-α-methylbenzylamine

References:

Suzuki, Mikio;Yanagawa, Yoshinobu;Iwasaki, Hiroshi;Kanda, Hiroyasu;Yanagihara, Kazufumi;Matsumoto, Hiroo;Ohara, Yoshio;Yazaki, Yukari;Sakoda, Ryozo [Bioorganic and Medicinal Chemistry Letters,1999,vol. 9,# 20,p. 2977 - 2982]

2-Cyclopropyl-4-(4-fluorophenyl)quinoline-3-carboxaldehyde

121660-37-5
180 suppliers
$9.00/250mg

254452-86-3
15 suppliers
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References

(E)-3-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl-2-propenal

148901-68-2
115 suppliers
inquiry

254452-86-3
15 suppliers
inquiry

References

256431-72-8 Synthesis

(E)-3-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-2-propenenitrile

256431-72-8
74 suppliers
inquiry

254452-86-3
15 suppliers
inquiry

References

148901-69-3 Synthesis

Ethyl (E)-7-[4-(4'-fluorophenyl)-2-(cyclopropyl)-3-quinolinyl]-5-hydroxy-3-oxo-6-heptenoate

148901-69-3
114 suppliers
$98.00/100mg

254452-86-3
15 suppliers
inquiry

References

(3S,5R,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid Related Search:

(4R,6S)-6-[(1E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester tert-Butyl (4R-cis)-6-formaldehydel-2,2-dimethyl-1,3-dioxane-4-acetate Tert-buthyl Pitavastatin Pitavastatin calcium (E)-3-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-2-propenenitrile

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(3S,5R,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid synthesis

(3S,5R,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid Related Search: