2-Thiopheneacetic acid synthesis
- Product Name:2-Thiopheneacetic acid
- CAS Number:1918-77-0
- Molecular formula:C6H6O2S
- Molecular Weight:142.18
57382-97-5
1918-77-0
Steps for the synthesis of 2-thiophene acetic acid: 1 g of ethyl 2-(thiophen-2-yl)acetate was dissolved in 4 mL of ethanol, 8 mL of 4N NaOH aqueous solution was added, and the reaction was stirred at room temperature for 1 hour. Upon completion of the reaction, the reaction mixture was adjusted to pH 1 with 1N HCl aqueous solution and subsequently extracted with dichloromethane. The organic phase was separated and concentrated under reduced pressure to remove the solvent to give the oily product 2-thiopheneacetic acid. The yield was close to quantitative.ESI-MS m/z: 141.0 [M-H]?
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1918-77-0
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Yield:1918-77-0 96.5%
Reaction Conditions:
with oxygen;triethylamine at 80; for 15 h;Reagent/catalyst;Temperature;
Steps:
1.1; 2.1; 3.1; 4.1; 5.1; 6.1; 7.1; 1-2 1. Preparation of 2-thiophene acetic acid
Dissolve 128 grams of 2-thiophene ethanol in 0.5 liter of anisole, stir and raise the temperature to 80°C,Add 5 grams of catalyst bentonite,60 grams of co-catalyst triethylamine,64 grams of dry oxygen is introduced,The aeration time is 5 hours, and the reaction is stirred at 80°C for 10 hours.After cooling down, it is separated and purified2-thiophene acetic acid was obtained, and the separation method was the same as that in Example 1.The yield was 96.5percent.The purity is higher than 99.5percent.
References:
Anda Haina Bell Chemical Co., Ltd.;Guo Qishuang;Liu Jing;Zhang Ming;Guo Wanbao;Wang Libao CN111560005, 2020, A Location in patent:Paragraph 0034-0037; 0041-0044; 0046-0049; 0051-0054; 0056
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