2-Phenylbenzoxazole synthesis
- Product Name:2-Phenylbenzoxazole
- CAS Number:833-50-1
- Molecular formula:C13H9NO
- Molecular Weight:195.22
273-53-0
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3240-34-4
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$7.00/10g
833-50-1
117 suppliers
$11.00/250mg
Yield:833-50-1 80%
Reaction Conditions:
with 1,10-Phenanthroline;palladium diacetate;caesium carbonate in dimethyl sulfoxide at 150; for 20 h;Inert atmosphere;
Steps:
1.1 General procedure of direct arylation of benzoxazole C-H bonds with iodobenzene diacetates
Gerenal procedure: Under N2, a reaction tube was charged with benzoxazole (0.2 mmol), PhI(OAc)2 (80.5 mg, 0.25 mmol), Pd(OAc)2 (2.2 mg, 5 mol %), 1,10-phenanthroline (7.9 mg, 10 mol %) and DMSO (2 mL). The mixture was stirred at 150 °C for 20 h. After the completion of the reaction, as monitored by TLC, 10 mL of ethyl acetate was added and the mixture was washed with water (3 × 5 mL). Then the organic layer was concentrated in vacuo and the residue was purified by flash column chromatography on a silica gel to give the desired product.
References:
Yu, Peng;Zhang, Guangyou;Chen, Fan;Cheng, Jiang [Tetrahedron Letters,2012,vol. 53,# 34,p. 4588 - 4590] Location in patent:supporting information; experimental part
95-55-6
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65-85-0
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833-50-1
117 suppliers
$11.00/250mg
93-98-1
243 suppliers
$15.00/5mg
833-50-1
117 suppliers
$11.00/250mg
98-88-4
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$10.00/5g
615-36-1
422 suppliers
$10.00/5g
833-50-1
117 suppliers
$11.00/250mg
