ChemicalBook CAS DataBase List 2-Nitrophenylboronic acid

2-Nitrophenylboronic acid synthesis

7synthesis methods

Product Name:2-Nitrophenylboronic acid
CAS Number:5570-19-4
Molecular formula:C6H6BNO4
Molecular Weight:166.93

98-80-6

5570-19-4

Using phenylboronic acid as starting material, nitric acid (126 g, 2 mol) and sodium nitrite (0.04 mol) were added dropwise to the reaction system and the reaction temperature was controlled at 45 °C. The reaction mixture was reacted with dimethylformamide (15 mol) under stirring conditions. Upon completion of the reaction, the mixture was poured completely into ice water, concentrated to a small volume, cooled and allowed to stand until a solid precipitate precipitated. The solid was separated by filtration and washed with ice water, and the final product 2-nitrophenylboronic acid 165.3 g was collected in 99.0% molar yield and >99.5% HPLC purity.

98-80-6 Synthesis

98-80-6
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$5.00/5g

5570-19-4
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$8.00/1g

Yield:5570-19-4 99%

Reaction Conditions:

with nitric acid;N,N-dimethyl-formamide;sodium nitrite at 45;Reagent/catalyst;Solvent;Temperature;

Steps:

6 Example 6:

Nitric acid (126 g, 2 mol) and sodium nitrite (0.04 mol) were added dropwise, and the reaction temperature was controlled at 45 °C, and the reaction mixture was stirred and reacted with dimethylformamide (15 mol). Completely poured into ice water, concentrated to a small volume, cooling, standing, until the solid precipitation, Filtration, ice water washing, collecting product 165.3g, molar yield 99.0%, HPLC greater than 99.5%.

References:

CN104788484,2017,B Location in patent:Paragraph 0026-0039