2-methoxypropionic acid synthesis
- Product Name:2-methoxypropionic acid
- CAS Number:4324-37-2
- Molecular formula:C4H8O3
- Molecular Weight:104.1
Yield: 99%
Reaction Conditions:
in methanol at 50;
Steps:
A.1
Sodium methoxide in methanol (25%, 16 mL) was added to a stirred solution of 2- bromopropionic acid (19.6 mmol) in methanol (5 mL) under nitrogen. The reaction was heated at 50 0C under nitrogen overnight. The reaction was then concentrated under vacuum. The residue was brought to pH 1 by the addition of 1 N aqueous HCl and this solution was then extracted with ethyl acetate three times (70 mL, 25 mL, 10 mL). The combined organic layer was dried (Na2SO4) and then concentrated under vacuum to yield the title compound as a colorless oil 2.04 g (99%) which was of sufficient purity to be used without purification. 1H NMR (CD3OD) δ 3.67 (q, IH), 3.33 (s, 3H), and 1.33 ppm (d, 3H).
References:
BAYER PHARMACEUTICALS CORPORATION WO2006/96338, 2006, A1 Location in patent:Page/Page column 41
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