2-Methoxy-5-(trifluoromethyl)aniline synthesis
- Product Name:2-Methoxy-5-(trifluoromethyl)aniline
- CAS Number:349-65-5
- Molecular formula:C8H8F3NO
- Molecular Weight:191.15
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349-65-5
Example 51 General procedure for the synthesis of 4-(8-methoxy-5-(trifluoromethyl)quinazolin-2-ylamino)phenyl)(morpholino)methanone (Compound 500) PP028218.0002: Step 1. Prepare a mixture of 2-methoxy-5-(trifluoromethyl)aniline A. A methanolic solution of 4-methoxy-3-nitrobenzotrifluoride and 10% Pd/C catalyst (10% loading) was stirred overnight at room temperature in a hydrogen atmosphere. Upon completion of the reaction, the mixture was filtered through a diatomaceous earth pad to remove the catalyst, and the filtrate was concentrated under reduced pressure and dried under vacuum to afford the target product 2-methoxy-5-(trifluoromethyl)aniline A in 99% yield as an off-white solid.ESI-MS m/z: 192.1 (MH+).
394-25-2
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349-65-5
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$5.00/1g
Yield:349-65-5 99%
Reaction Conditions:
with hydrogen;palladium 10% on activated carbon in methanol at 20;
Steps:
51.1
Example 51Synthesis of 4-(8-methoxy-5- (trifluorornethyl) quinazolin-2-ylamino) phenyl)(moφholino)methanone (Compound 500)
References:
WO2007/117607,2007,A2 Location in patent:Page/Page column 363-364
402-52-8
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349-65-5
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402-10-8
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$10.00/1g
349-65-5
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98-56-6
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349-65-5
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$5.00/1g