2-(hydroxymethyl)benzohydrazide(SALTDATA: FREE) synthesis
- Product Name:2-(hydroxymethyl)benzohydrazide(SALTDATA: FREE)
- CAS Number:51707-35-8
- Molecular formula:C8H10N2O2
- Molecular Weight:166.18
41150-46-3
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51707-35-8
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Yield:51707-35-8 70%
Reaction Conditions:
with hydrazine hydrate in methanol; for 48 h;
Steps:
Preparation of hydrazide: A typical procedure 1
General procedure: A solution of methyl 4-tert-butylbenzoate (5.15 g, 26.8 mmol) and hydrazine monohydrate (1.50 ml, 30.0 mmol) in MeOH (15 mL) was stirred for 2 d. After the removal of the solvent in vacuo, the residue was recrystallized from MeOH to give 4-tert-butylbenzohydrazide (1b) (2.94 g, 15.3 mmol, 57%) as a colorless crystal. 1 H-NMR (300 MHz, DMSO-d 6 ): δ 9.68 (s, 1H), 7.75 (d, J = 8.5 Hz, 2H), 7.45 (d, J = 8.5 Hz, 2H), 4.44 (s, 2H), 1.28 (s, 9H) ppm.
References:
Sakurai, Masayoshi;Kawakami, Rina;Kihara, Nobuhiro [Tetrahedron Letters,2019,vol. 60,# 18,p. 1291 - 1294] Location in patent:supporting information
87-41-2
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51707-35-8
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87-41-2
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64-17-5
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7803-57-8
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51707-35-8
14 suppliers
$28.60/50mg