2-CHLORO-N,N-DIMETHYL-4-NITROANILINE synthesis
- Product Name:2-CHLORO-N,N-DIMETHYL-4-NITROANILINE
- CAS Number:6213-19-0
- Molecular formula:C8H9ClN2O2
- Molecular Weight:200.62
64-18-6
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6213-19-0
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Yield: 1.54 g
Reaction Conditions:
with sodium tetrahydroborate at 0 - 20; for 2 h;Cooling with ice;
Steps:
IIb-3 5,5'-disulfanediylbis(2-chloro-N1 ,N1-dimethylbenzene-1,4-diamine)
2-Chloro-4-nitroaniline (1 .5 g, 8.6 mmol) was dissolved in formic ac- id (20 ml). The mixture was cooled to 0°C in an ice bath and NaBH4(1 .31 g, 34.7 mmol) was added portion wise. During the addition, the temperature was not allowed to rise above 5°C. After addition was complete, the mixture was allowed to warm to RT and stirred at RT for 2 hours. After completion of the reaction, the mixture was poured into ice water. Aqueous NH4CI solution was added to quench unreacted NaBH4. The mixture was neutralized wit aqueous NaHCO3and extracted with ethyl acetate. The organic layer was dried over sodium sulphate and concentrated under reduced pressure. The yield of 2- chloro-N,N-dimethyl-4-nitroaniline after flash chromatography (100-200 mesh size silica gel, 2% ethyl acetate in hexane) was 1 .54 g.
References:
MEDEIA THERAPEUTICS LTD;RATILAINEN, Jari;GOLDSTEINS, Gundars WO2014/191632, 2014, A1 Location in patent:Page/Page column 52; 53
121-87-9
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74-88-4
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6213-19-0
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350-30-1
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506-59-2
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6213-19-0
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100-23-2
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6213-19-0
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680-31-9
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99-54-7
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6213-19-0
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$22.89/250mg