2-Bromo-3-fluorophenol synthesis
- Product Name:2-Bromo-3-fluorophenol
- CAS Number:443-81-2
- Molecular formula:C6H4BrFO
- Molecular Weight:191
324769-11-1
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443-81-2
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Yield:443-81-2 84%
Reaction Conditions:
with hydrogenchloride;water in isopropyl alcohol at 20; for 2.5 h;
Steps:
XIX 2-bromo-3-fluorophenol
A mixture of 120 ML isopropanol, 200 ML 6M hydrochloric acid, and 81 gm (345 MMol) 1-(methoxymethoxy)-2-bromo-3-fluorophenol was stirred at room temperature.. After 2.5 hours the reaction mixture was partitioned by the addition of 400 ML methyl tert-butyl ether and 120 ML 5N sodium hydroxide.. The organic phase was washed with saturated aqueous sodium chloride, dried over sodium sulfate and concentrated under reduced pressure.. The residual oil was subjected to silica gel chromatography, eluding with dichloromethane.. Fractions containing product were combined and concentrated under reduced pressure to provide 55.1 gm (84%) of the desired compound as a colorless oil.
References:
EP1204660,2004,B1 Location in patent:Page 19
372-20-3
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443-81-2
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446-59-3
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443-81-2
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863870-75-1
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443-81-2
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64248-56-2
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443-81-2
172 suppliers
$18.00/1g