2-(Aminomethyl)-1-ethylpyrrolidine synthesis
- Product Name:2-(Aminomethyl)-1-ethylpyrrolidine
- CAS Number:26116-12-1
- Molecular formula:C7H16N2
- Molecular Weight:128.22
2167-14-8
26116-12-1
General procedure for the synthesis of N-ethyl-2-aminomethylpyrrolidine from 1-ethyl-1H-pyrrole-2-carboxaldehyde: 60 g of 1-ethyl-1H-pyrrole-2-carboxaldehyde was added to an autoclave, and 5 g of palladium-carbon catalyst at a mass percent concentration of 5% and 15 g of liquid ammonia were added to carry out hydrogenation and reductive amination reactions. The reaction conditions were hydrogen pressure of 35 kg and temperature of 95°C. After completion of the reaction, the system was cooled, the gas was expelled, and filtration was carried out. The filter cake was washed with methanol, and the filtrate and washings were combined to recover methanol. Finally, the target product N-ethyl-2-aminomethylpyrrole was obtained by purification via decompression distillation in a yield of 53.7 g and 86%. The reaction equation was as follows:
2167-14-8
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26116-12-1
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Yield:26116-12-1 86%
Reaction Conditions:
with 5%-palladium/activated carbon;ammonia;hydrogen at 95;Autoclave;
Steps:
4 Example 4 Preparation of 1-(1-ethylpyrrolidin-2-yl)methanamine
Take 60 g of Example 3 N-ethylpyrrole formaldehyde product into the autoclave,Add mass percent concentration of 5% palladium-carbon (5 g) and liquid ammonia 15 g,Hydrogenation and reductive amination under hydrogen pressure of 35 kg and 95°CAfter the reaction, cooling, exhaust, suction filtration, methanol washing,Methanol was recovered, and then the product N-ethyl-2-aminomethylpyrrole (53.7 g) was obtained by distillation under reduced pressure. The yield was 86%. The reaction equation was as follows:
References:
Jiangsu Kangheng Chemical Co., Ltd.;Qiu Zhigang CN107973735, 2018, A Location in patent:Paragraph 0017; 0027-0029
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