ChemicalBook CAS DataBase List 2-Amino-5-chloro-3-methylbenzoic acid

2-Amino-5-chloro-3-methylbenzoic acid synthesis

13synthesis methods

Product Name:2-Amino-5-chloro-3-methylbenzoic acid
CAS Number:20776-67-4
Molecular formula:C8H8ClNO2
Molecular Weight:185.61

4389-45-1

20776-67-4

General procedure for the synthesis of 2-amino-5-chloro-3-methylbenzoic acid from 2-amino-3-methylbenzoic acid: In a 100 mL round-bottomed flask, 20 mL of 2-amino-3-methylbenzoic acid, 50 mL of N,N-dimethylformamide (DMF), and 30 mmol of N-chlorosuccinimide (or N-bromosuccinimide) were added. The mixture was stirred under reflux conditions for 3 hours. After the reaction was completed, the reaction solution was poured into ice water. The pH was adjusted to 6 with dilute hydrochloric acid and then filtered. The resulting solid was washed with a small amount of ethanol to give a gray solid 2-amino-5-halogeno-3-methylbenzoic acid (halogen was chlorine or bromine). The yield was 83%.

4389-45-1 Synthesis

4389-45-1
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$5.00/5g

20776-67-4
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$6.00/5g

Yield:20776-67-4 98.1%

Reaction Conditions:

with chlorine in 1,2-dichloro-ethane at 50; for 3 h;Solvent;

Steps:

1-3 Preparation of K2.2-amino-5-chloro-3-methylbenzoic acid
Put 8g (53mmol) of 2-amino-3-methylbenzoic acid in the flask, add 40g of dichloroethane, turn on the stirring, heat up to 50°C and then slowly pass in 4.5g (63.4mmol) of chlorine for reaction for 3h.After the reaction, it was lowered to room temperature and filtered to obtain 9.6 g of 2-amino-5-chloro-3-methylbenzoic acid (3), with a yield of 98.1%

References:

Jiangsu Qi Zhou Green Chemical Co., Ltd.;Zhang Hu;Zhou Wei;Xu Qiulong;Zhou Zhihao;Chu Xiaojing CN111517975, 2020, A Location in patent:Paragraph 0056; 0059-0060; 0065; 0068-0069; 0074; 0077; 0078

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14389-06-1 Synthesis