2-AMINO-5-(4-NITROPHENYL)-1 3 4-THIADIA& synthesis
- Product Name:2-AMINO-5-(4-NITROPHENYL)-1 3 4-THIADIA&
- CAS Number:833-63-6
- Molecular formula:C8H6N4O2S
- Molecular Weight:222.22
Yield:833-63-6 90%
Reaction Conditions:
with trichlorophosphate at 75; for 0.5 h;
Steps:
General Procedure for Preparing 5-substituted-1,3,4-thiadiazol-2-amine.
General procedure: A stirring mixture of benzoic acid (7.32 g, 60 mmol), N-aminothiourea(6.38 g, 70 mmol) and POCl3 (20 ml) washeated at 75 °C for 0.5 h. After cooling down to room temperature,water was added. The reaction mixture was refluxedfor 4 h. After cooling, the mixture was basified to pH8 by the drop-wise addition of 50% NaOH solution understirring. The precipitate was filtered and re-crystallized from ethanol
References:
Tu, Guo Gang;Zhan, Jian Feng;Lv, Qiao Li;Wang, Jia Qi;Kuang, Bin Hai;Li, Shao Hua [Medicinal Chemistry,2014,vol. 10,# 4,p. 376 - 381]
836-16-8
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