2-AMINO-4,5-DIMETHYLBENZONITRILE synthesis
- Product Name:2-AMINO-4,5-DIMETHYLBENZONITRILE
- CAS Number:28568-03-8
- Molecular formula:C9H10N2
- Molecular Weight:146.19
15089-77-7
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Yield:-
Reaction Conditions:
with sodium carbonate;sodium nitrite in hydrogenchloride;water;acetic acid;toluene;
Steps:
F.50 Synthesis of the starting material for Example 50
Synthesis of the starting material for Example 50 0.41 g Sodium nitrite in water is added to 1 g 4,5-dimethyl-2-nitroaniline in 3 mL conc. HCl and stirred for 1 hour at +4° C. This solution is added to a mixture of 0.67 g copper (I) cyanide, 0.98 g sodium cyanide, 0.32 g sodium carbonate, 25 mL of water and 3 mL toluene. The mixture is stirred for 12 hours at room temperature and worked up to give 0.45 g 4,5-dimethyl-2-nitrobenzonitrile. 4,5-Dimethyl-2-nitrobenzonitrile is reduced with iron powder in acetic acid to yield 4,5-dimethyl-2-aminobenzonitrile.
References:
US2002/19414,2002,A1
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