ChemicalBook CAS DataBase List 2,7-Dihydroxy-9-fluorenone

2,7-Dihydroxy-9-fluorenone synthesis

12synthesis methods

Product Name:2,7-Dihydroxy-9-fluorenone
CAS Number:42523-29-5
Molecular formula:C13H8O3
Molecular Weight:212.2

[1,1'-Biphenyl]-2-carboxylic acid, 4,4'-dihydroxy-, methyl ester

765944-63-6

42523-29-5

Methyl 4,4'-dihydroxy-[1,1'-biphenyl]-2-carboxylate (50 g, 0.20 mol) was used as a raw material and mixed with ZnCl2 (50 g, 0.37 mol) and polyphosphoric acid (PPA, 33 mL). The reaction mixture was stirred at 110-120 °C for 2 hours. Upon completion of the reaction, it was cooled to room temperature and water (500 mL) was slowly added to precipitate the product. The precipitate was collected by filtration and dried to give 40 g of reddish brown crystalline powder (2,7-dihydroxy-9-fluorenone). The yield was 95%; melting point 336-337°C (literature value 338°C [24]); IR (KBr) ν (cm^-1): 3388.9, 3360.6 (OH), 1700.7 (C=O); ESI-MS (m/z): 211.0 [M+H]^+, molecular formula C13H8O3 (molecular weight 212.0); 1H- NMR (300MHz, DMSO-d6) δ (ppm): 9.89 (s, 2H), 7.37 (d, J=4.8Hz, 2H), 6.90 (dd, J=4.9,2.4Hz, 2H), 6.86 (d, J=2.4Hz, 2H).

14348-75-5 Synthesis

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Yield:42523-29-5 865 mg

Reaction Conditions:

with lithium hydroxide monohydrate;N₁,N₂-bis(4-hydroxy-2,6-dimethylphenyl)oxalamide;copper(II) acetylacetonate in water;dimethyl sulfoxide at 120; for 4 h;

Steps:

4 Synthesis of 2,7-dihydroxyfluoren-9-one using bis (2,4-pentanedionato) copper (II)

2,7-dibromofluoren-9-one (manufactured by Tokyo Chemical Industry Co., Ltd., 1.35 g, 4.0 mmol),Lithium hydroxide monohydrate (704 mg, 16.8 mmol),Bis (2,4-pentanedionato) copper (II) (53.6 mg, 0.20 mmol),A mixture of N, N'-bis (2,6-dimethyl-4-hydroxyphenyl) oxamide (65.0 mg, 0.20 mmol) and DMSO / water (9.6 mL / 2.4 mL) at 120 ° C. for 4 hours Heated and stirred. After cooling to room temperature, the reaction mixture is diluted with waterFurthermore, 3 M hydrochloric acid is added to adjust the pH to acidic,The resulting red solid was collected by filtration and vacuum dried (100 ° C., overnight).The target 2,7-dihydroxyfluoren-9-one was obtained as a red solid (865 mg, quantitative, HPLC purity: 85.6%).

References:

JP2019/77634,2019,A Location in patent:Paragraph 0106-0108

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42523-29-5
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References