2,6-DICHLORO-4-METHOXY-PYRIDINE synthesis
- Product Name:2,6-DICHLORO-4-METHOXY-PYRIDINE
- CAS Number:17228-75-0
- Molecular formula:C6H5Cl2NO
- Molecular Weight:178.02
67-56-1
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16063-69-7
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17228-75-0
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Yield:17228-75-0 94%
Reaction Conditions:
with sodium hydride in N,N-dimethyl-formamide;mineral oil at 0 - 20; for 16 h;
Steps:
1 1. Preparation of 2, 6-dichloro-4-methoxypyridine
To a solution of 2,4,6-trichloropyridine (3.64 g, 20.0 mmol) in DMF (20 mL) at 0°C were slowly added NaH (60% in mineral oil, 840 mg, 21 mmol) and MeOH (673 mg, 21 mmol). The mixture was stirred at room temperature for 16 h. The mixture was concentrated and partitioned between EtOAc (30 mL) and water (15 mL). The organic extracts were dried (Na2SO4), filtered, and concentrated. The residue was purified by silica gel chromatography eluting with ethyl acetate in hexane (0-5 percent) to afford the title compound (3.0 g, yield: 94%).
References:
NEW ERA PHARMA, INC.;XIAN, Jun WO2018/106459, 2018, A1 Location in patent:Paragraph 00110
16063-69-7
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$40.00/5g
124-41-4
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$12.00/25g
17228-75-0
118 suppliers
$17.00/250mg
67-56-1
780 suppliers
$7.29/5ml-f
25194-01-8
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$10.00/1g
17228-75-0
118 suppliers
$17.00/250mg
38608-87-6
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17228-75-0
118 suppliers
$17.00/250mg
25194-01-8
183 suppliers
$10.00/1g
17228-75-0
118 suppliers
$17.00/250mg