ChemicalBook CAS DataBase List 2,4'-Difluorobenzophenone

2,4'-Difluorobenzophenone synthesis

6synthesis methods

Product Name:2,4'-Difluorobenzophenone
CAS Number:342-25-6
Molecular formula:C13H8F2O
Molecular Weight:218.2

352-13-6

393-52-2

342-25-6

The general procedure for the synthesis of (2-fluorophenyl)(4-fluorophenyl)methanone from 4-fluorophenylmagnesium bromide and o-fluorobenzoyl chloride was as follows: 2-fluorobenzoyl chloride (6 mmol, 1.0 eq.) was dissolved in 2-methyltetrahydrofuran (15 mL) and transported through the material channel A and the metering pump P1; meanwhile, 4-fluorophenylmagnesium bromide (9 mmol, 1.5 eq.) was dissolved in 2- methyltetrahydrofuran (15 mL), delivered through material channel B and metering pump P2. The two solutions were mixed in the mixing module M at a preset temperature of 25 °C and a flow rate of 1 mL/min, and then entered into the reaction module L for 1 hour. Upon completion of the reaction, the reaction solution flowed out of outlet D and was collected in 1 mol/L hydrochloric acid solution for quenching. The quenched solution was stirred, washed with saturated brine solution, dried with anhydrous sodium sulfate, concentrated and purified by column chromatography to afford the target product (2-fluorophenyl)(4-fluorophenyl)methanone.

1765-93-1 Synthesis

1765-93-1
552 suppliers
$9.00/1g

446-52-6 Synthesis

446-52-6
440 suppliers
$6.00/25g

342-25-6
306 suppliers
$6.00/5g

Yield:342-25-6 98%

Reaction Conditions:

with potassium phosphate;palladium diacetate in water;methyl cyclohexane; for 8 h;Reflux;Solvent;

Steps:

3 Example 3

Method of the present embodiment provides a 2,4 ′-difluorobenzophenone and preparation method thereof, as follows: in a 1000 ml round bottom flask The bottle was added sequentially o-fluoro benzaldehyde 124 g of 4-fluorophenylboronic acid and 140 g of potassium phosphate, 106 grams, 1.12 g of palladium acetate, then adding 500 ml of methyl cyclohexane and 100 ml of water and heated to reflux for 8 hours., sequentially passes through filtering, layering, washing with water, removing the solvent to obtain the product., 2,4 '-difluorobenzophenone 214 g, 98% yield.

References:

CN104230691,2016,B Location in patent:Paragraph 0028-0029