(2,3-dihydroxypropyl)trimethylammonium chloride synthesis
- Product Name:(2,3-dihydroxypropyl)trimethylammonium chloride
- CAS Number:34004-36-9
- Molecular formula:C6H16ClNO2
- Molecular Weight:169.6497
96-24-2
75-50-3
34004-36-9
General procedure for the synthesis of 2,3-dihydroxypropyl-trimethylammonium chloride from 3-chloro-1,2-propanediol and trimethylamine: 0.00 g (±)-3-chloro-1,2-propanediol (0.452 mol), 178.00 g of a 30% aqueous solution of trimethylamine (0.904 mol), and 50 mL of deionized water were added to a 500 mL three-neck flask. Subsequently, the reaction system was warmed to 90 °C and stirred continuously at this temperature for 16 hours to ensure complete reaction of 3-chloro-1,2-propanediol. Upon completion of the reaction, the reaction mixture was cooled to 20 °C and extracted three times with ethyl acetate (100 mL x 3) to remove organic impurities. The aqueous phase was collected and concentrated to dryness by rotary evaporator to give 70.00 g of white solid product in 91.2% yield and 93.40% purity by HPLC.
96-24-2
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75-50-3
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$15.00/25ml
34004-36-9
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$89.00/250mg
Yield: 91.2%
Reaction Conditions:
in water at 90; for 16 h;
Steps:
1 Synthesis of (±) -2,3-dihydroxypropyl trimethylammonium chloride
0.00 g of (±)-3-chloro-1,2-propanediol (0.452 mol), 178.00 g of a 30% aqueous solution of trimethylamine (0.904 mol) and 50 mL of water were added to a 500 mL vial.Then, the temperature was raised to 90 ° C, and the mixture was stirred for 16 hours to complete the reaction of the raw material 3-chloro-1,2-propanediol.The temperature was lowered to 20 ° C, and the reaction mixture was washed three times with ethyl acetate (100 mL×3), and the aqueous solution was collected and concentrated to dryness to give a white solid (70.00 g), yield 91.2%, HPLC purity 93.40%.
References:
Aisite (Chengdu) Bio-pharmaceutical Co., Ltd.;Wen Wandong;Ding Gang;Hu Zhipeng;Cheng Rui;Guo Peng CN108129338, 2018, A Location in patent:Paragraph 0027; 0029; 0030
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$13.00/25g
34004-36-9
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$89.00/250mg
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$18.30/50ml
75-50-3
287 suppliers
$15.00/25ml
34004-36-9
50 suppliers
$89.00/250mg