2,3-Diamino-5-methylpyridine synthesis
- Product Name:2,3-Diamino-5-methylpyridine
- CAS Number:24638-29-7
- Molecular formula:C6H9N3
- Molecular Weight:123.16
7598-26-7
24638-29-7
The general procedure for the synthesis of 2,3-diamino-5-methylpyridine from 2-amino-3-nitro-5-methylpyridine was as follows: the Pd/C catalyst (50 mg, 0.47 mmol) was added to a stirring solution of 2-amino-5-methyl-3-nitropyridine (500 mg, 3.27 mmol) in methanol (7 mL). Subsequently, the reaction system was evacuated three times and charged with hydrogen displacement. The reaction was stirred at 20 °C for 5 h under hydrogen atmosphere. Upon completion of the reaction, the reaction mixture was filtered through diatomaceous earth and the filter cake was washed with additional methanol (30 mL). The filtrate was concentrated under reduced pressure to afford the target product 2,3-diamino-5-methylpyridine (395 mg, 98% yield). The product was characterized by 1H NMR (MeOD): δ 7.22 (dd, J = 2.0, 0.9 Hz, 1H), 6.81 (dd, J = 2.0, 0.7 Hz, 1H), 2.13 (t, J = 0.7 Hz, 3H). Mass spectral analysis showed m/z = 124 (100).
1603-41-4
546 suppliers
$7.00/25g
24638-29-7
82 suppliers
$45.00/50mg
Yield:-
Steps:
Multi-step reaction with 2 steps
1: 25 percent / H2SO4, 70percent HNO3 / 2 h / 55 °C
2: 99 percent / H2 / 5percent Pd/C / methanol / 3 h / 1034.3 - 1551.4 Torr
References:
Cai, Sui Xiong;Huang, Jin-Cheng;Espitia, Stephen A.;Tran, Minhtam;Ilyin, Victor I.;Hawkinson, Jon E.;Woodward, Richard M.;Weber, Eckard;Keana, John F.W. [Journal of Medicinal Chemistry,1997,vol. 40,# 22,p. 3679 - 3686]
7598-26-7
140 suppliers
$35.35/1gm:
24638-29-7
82 suppliers
$45.00/50mg