(1R,2S,5R)-(-)-MENTHYL (S)-P-TOLUENESULFINATE synthesis
- Product Name:(1R,2S,5R)-(-)-MENTHYL (S)-P-TOLUENESULFINATE
- CAS Number:1517-82-4
- Molecular formula:C17H26O2S
- Molecular Weight:294.45
536-57-2
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2216-51-5
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1517-82-4
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$21.00/1g
Yield: 99%
Reaction Conditions:
with dmap;1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane at 25; for 16 h;Inert atmosphere;Temperature;Reagent/catalyst;
Steps:
4-Bromobenzyl p-Toluenesulfinate (1c), Typical Procedure
General procedure: To a 250 mL flame-dried N2 purged round-bottomed flask was added p-toluenesulfinic acid (0.525 g, 3.36 mmol), 4-bromobenzyl alcohol (0.598 g, 3.20 mmol), and DMAP (0.078 g, 0.64 mmol) sequentially and dissolved in anhyd CH2Cl2 (14 mL). To the solution was added 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (0.644 g, 3.36 mmol) in one portion and stirred for 16 h at r.t. The reaction mixture was diluted with CH2Cl2 (30 mL) and washed with aq 1 M HCl (30 mL) and brine (30 mL). The organic layer was dried (MgSO4), filtered, and solvents removed under reduced pressure. The crude product was purified by flash column chromatography .
References:
Gafur, Sayed Habibul;Waggoner, Stephanie L.;Jacobsen, Eric;Hamaker, Christopher G.;Hitchcock, Shawn R. [Synthesis,2018,vol. 50,# 24,art. no. SS-2018-M0396-OP,p. 4855 - 4866]
10439-23-3
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2216-51-5
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98147-48-9
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1517-82-4
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2216-51-5
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$5.00/100mg
![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
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1517-82-4
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184636-51-9
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2216-51-5
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98-59-9
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1517-82-4
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$21.00/1g
2216-51-5
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$5.00/100mg
19158-51-1
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$52.00/1 g
1517-82-4
125 suppliers
$21.00/1g