1,1,1-trifluoro-2-(4-methylpyridin-2-yl)propan-2-ol synthesis
- Product Name:1,1,1-trifluoro-2-(4-methylpyridin-2-yl)propan-2-ol
- CAS Number:1396893-43-8
- Molecular formula:C9H10F3NO
- Molecular Weight:205.18
1396893-42-7
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Yield:-
Reaction Conditions:
with methanol;potassium carbonate at 20; for 1 h;
Steps:
4
1.1,1 -Trifluoro-2-(4-methylpyridin-2-yl)propan-2-ol (c). To a solution of 4-methyl-2- (2,2,2-trifluoro-l -methyl- l-trimethylsilanyloxy-ethyl)pyridine (b) (346 g, 125 mmol, 1.0 equiv.) in 1.5 L MeOH at room temperature was added solid K2C03 (344 g, 249 mmol, 2.0 equiv.). The resulting beige suspension was stirred at room temperature for 1 hour, then filtered over filter paper. The filtrate was concentrated in vacuo to give a solid, intensively smelling residue. The residue was dissolved in 1 L ethyl acetate and washed with water (2 x 1 L). After drying over MgS04 and filtration, concentration in vacuo provided 252 g (98%) of alcohol (c) as an oil.
References:
WO2012/117071,2012,A1 Location in patent:Page/Page column 24-25
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