1-Amino-1-(hydroxymethyl)cyclopropane hydrochloride synthesis
- Product Name:1-Amino-1-(hydroxymethyl)cyclopropane hydrochloride
- CAS Number:115652-52-3
- Molecular formula:C4H9NO.HCl
- Molecular Weight:123.58
107017-73-2
115652-52-3
8.2 Synthesis of 1-aminocyclopropane methanol hydrochloride 1.04 g of tert-butyl (1-hydroxymethylcyclopropyl)-carbamate was dissolved in 5 mL of dioxane. Under stirring, 2.5 mL of 4 mol/L HCl in dioxane solution was added slowly and dropwise. The reaction mixture was stirred at room temperature for 15 hours. Subsequently, the solvent was evaporated to half of the original volume and the precipitated solid was collected by filtration. 0.5 g of the target product 1-aminocyclopropanemethanol hydrochloride was finally obtained. The structure of the product was confirmed by 1H NMR (400 MHz, DMSO): δ 5.27 (1H, t), 0.91 (2H, t), 0.71 (2H, t).
107017-73-2
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115652-52-3
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$8.00/100mg
Yield:-
Reaction Conditions:
with hydrogenchloride in 1,4-dioxane at 20;
Steps:
8.2 8.2 1-aminocyclopropanemethanol
8.2 1-aminocyclopropanemethanol 1.04 g tert-butyl (1-hydroxymethylcyclopropyl)-carbamidate are placed in 5 ml dioxane. 2.5 ml HCl in dioxane (4 mol/l) are added dropwise. The reaction mixture is stirred for 15 h at ambient temperature. The solvent is evaporated down by half and the precipitated solid is suction filtered. 0.5 g product are obtained as the hydrochloride. 1H NMR (400 MHz, DMSO): 5.27 (1H, t); 0.91 (2H, t); 0.71 (2H, t).
References:
BOEHRINGER INGELHEIM INTERNATIONAL GMBH US2010/305102, 2010, A1 Location in patent:Page/Page column 16