1-(CHLOROACETYL)-5-NITROINDOLINE synthesis
- Product Name:1-(CHLOROACETYL)-5-NITROINDOLINE
- CAS Number:87866-11-3
- Molecular formula:C10H9ClN2O3
- Molecular Weight:240.64
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Yield:87866-11-3 92%
Reaction Conditions:
in ethyl acetate at 40 - 80; for 0.5 h;
Steps:
1.1 (1) Preparation of 1-(2-chloroacetyl)-5-nitroindoline
(1) Preparation of 1-(2-chloroacetyl)-5-nitroindoline
5-nitroindoline (16.4g, 100mmol) was dissolved in ethyl acetate (200ml), and then chloroacetyl chloride (9.6ml 120mmol) was slowly added at 40 °C. The resulting mixture was heated to 80 °C, and reacted for 0.5 hour. The reaction mixture was cooled and filtered by suction. The filtrate was crystallized to produce 1-(2-chloroacetyl)-5-nitroindoline (22g) as a grey solid in a yield of 92%.
References:
EP2930167,2015,A1 Location in patent:Paragraph 0103; 0104
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