ChemicalBook CAS DataBase List 1-BROMO-2-NAPHTHOIC ACID

1-BROMO-2-NAPHTHOIC ACID synthesis

10synthesis methods

Product Name:1-BROMO-2-NAPHTHOIC ACID
CAS Number:20717-79-7
Molecular formula:C11H7BrO2
Molecular Weight:251.08

76635-70-6

20717-79-7

4) 1.59 g of 2-hydroxymethyl-1-bromonaphthalene and 22 mL of acetone were added to a 250 mL round bottom flask and heated to reflux. 3.67 g of potassium permanganate was dissolved in 8.1 mL of water and 55 mL of acetone, heated and slowly added to the round-bottomed flask, and the reaction mixture was maintained at reflux for 30 min, then continued at reflux for 5 hr. The solution gradually turned brown during the reaction and the heating was stopped when the reaction was completed. The reaction mixture was filtered to remove the resulting MnO2 solid precipitate and the precipitate was washed with ether. Concentration of the filtrate gave 1.32 g of the target product 1-bromo-2-naphthoic acid in 78.6% yield.

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Yield:20717-79-7 78.6%

Reaction Conditions:

with potassium permanganate in water;acetone; for 5.5 h;Reflux;

Steps:

1.4

4) in a 250 ml round-bottom flask by adding 1.59g1-bromo-2-hydroxy methyl naphthalene and 22 ml acetone, heating to reflux. The 3.67g potassium permanganate dissolved in 8.1 ml water and 55 ml acetone, the add drop after heating thereof in the round-bottom flask, the 30 min, heat to reflux and 5h, the solution becomes brown, stop should be instead instead, filtering, the generated MnO₂solid precipitate is filtered, washing with ethyl ether. Concentrated to obtain the product (1-bromo-2-naphthoic acid) 1.32g, the yield is 78.6%.

References:

CN105541605,2016,A Location in patent:Paragraph 0017; 0026; 0035; 0044; 0071; 0080

2586-62-1 Synthesis