1-Bromo-2-methoxy-3-nitro-benzene synthesis
- Product Name:1-Bromo-2-methoxy-3-nitro-benzene
- CAS Number:98775-19-0
- Molecular formula:C7H6BrNO3
- Molecular Weight:232.03
27684-84-0
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$9.00/1g
74-88-4
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$15.00/10g
98775-19-0
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$8.00/250mg
Yield:98775-19-0 76%
Reaction Conditions:
with potassium carbonate in acetone for 24 h;Heating / reflux;
Steps:
3.b b) 2-Bromo-6-nitroanisole
A mixture of the compound from Example 2a) (10.8 g; 0.0495 mol.), methyl iodide (3.4 mL; 0.00545 mol.) and potassium carbonate (8.2 g; 0.0592 mol.) in acetone (250 mL) was stirred and heated under reflux for 24 h. [0392] The mixture was evaporated and the residue triturated with water to afford the title compound (8.7 g; 76%). mp 55-56° C. 1H NMR (300 MHz, CDCl3 δ 7.81-7.74 (m, 2H), 7.13 (t, J=8.1 Hz, 1H), 4.02 (s, 3H); Anal. (C7H6NO3Br) calcd: C, 36.24; H, 2.61; N, 6.04. found: C, 36.30; H, 2.59; N, 5.73.
References:
Erickson-Miller, Connie J;Eppley, Daniel F.;Jenkins, Julian;Luengo, Juan I.;Liu, Nannan;Price, Alan T.;Shaw, Anthony N.;Visonneau, Sophie;Wiggall, Kenneth US2004/19190, 2004, A1 Location in patent:Page 18
13073-25-1
344 suppliers
$6.00/1g
74-88-4
353 suppliers
$15.00/10g
98775-19-0
198 suppliers
$8.00/250mg
3970-37-4
130 suppliers
$11.00/250mg
124-41-4
717 suppliers
$12.00/25g
98775-19-0
198 suppliers
$8.00/250mg
578-57-4
305 suppliers
$6.00/10g
5197-28-4
196 suppliers
$10.00/5g
98775-19-0
198 suppliers
$8.00/250mg
13073-25-1
344 suppliers
$6.00/1g
77-78-1
321 suppliers
$19.69/1ml
98775-19-0
198 suppliers
$8.00/250mg