1,3-Dioxo-2-isoindolineaceticacid synthesis
- Product Name:1,3-Dioxo-2-isoindolineaceticacid
- CAS Number:6296-53-3
- Molecular formula:C10H7NO4
- Molecular Weight:205.17
603-11-2
648 suppliers
$15.00/25 g
108-24-7
0 suppliers
$14.00/250ML
6296-53-3
306 suppliers
$6.00/250mg
Yield:6296-53-3 83%
Reaction Conditions:
with palladium 10% on activated carbon;hydrogen at 80 - 115; under 7500.75 Torr;Autoclave;Temperature;
Steps:
6 Preparation of 3-acetylamino phthalic anhydride
2-nitrophthalic acid (100. 0 g), acetic anhydride (1 L) was added to a hydrogenation kettle, heated to 80 ° C,After the raw material disappeared, the mixture was cooled to room temperature, 10% Pd / C (3 g) was added, replaced with nitrogen twice, hydrogen was introduced to IMPa,The reaction is maintained at room temperature until no hydrogen is absorbed, vented, blown with nitrogen,Heated to 110-115 ° C reaction to the raw material or intermediate state disappeared,Hot filter, cooled to 0-5 ° C, filtered, washed with glacial acetic acid to give pale yellow crystals, dried 80. 6g, yield 83%, HPLC 99. 0%.
References:
Shanghai UTOpharm Company Limited;Luo, junzhi;Zeng, YuPing CN105294534, 2016, A Location in patent:Paragraph 0036; 0037
5434-20-8
251 suppliers
$41.00/1g
108-24-7
0 suppliers
$14.00/250ML
6296-53-3
306 suppliers
$6.00/250mg
5434-20-8
251 suppliers
$41.00/1g
6296-53-3
306 suppliers
$6.00/250mg
108-24-7
0 suppliers
$14.00/250ML
6946-22-1
181 suppliers
$33.10/1g
6296-53-3
306 suppliers
$6.00/250mg
603-11-2
648 suppliers
$15.00/25 g
6296-53-3
306 suppliers
$6.00/250mg