CAS NO.18030-61-0 p-Trichlorosilylbiphenyl is an organic silicon compound with a trichlorosilyl (- SiCl₃) and biphenyl structure. Due to its unique chemical properties, this compound has potential application value in the fields of organic synthesis, materials science, and chromatographic separation.

1. Chromatography technology is an indispensable separation method in modern analytical chemistry, and its core lies in the selection and optimization of the stationary phase. In recent years, with the increasing demand for analysis of complex samples such as biomolecules, environmental pollutants, drug metabolites, etc., the development of new stationary phases has become a research hotspot. CAS NO.18030-61-0 p-Trichlorosilylbiphenyl, as a compound with reactive silane groups and rigid biphenyl skeleton, may provide new ideas for the design of chromatographic stationary phases.

2. Chemical characteristics

2.1 Molecular Structure and Reactivity

The molecular structure of CAS NO.18030-61-0 p-Trichlorosilylbiphenyl consists of two parts:

Biphenyl group: It has a rigid planar structure and a π - electron conjugated system, and can participate in hydrophobic interactions and π - π stacking.

Trichlorosilyl (- SiCl₃): It has high reactivity and can undergo condensation reactions with surfaces containing hydroxyl groups (- OH), such as silica gel and metal oxides, to form stable Si-O-Si bonds.

The reactivity of this compound makes it suitable for surface modification, especially in the preparation of chromatographic stationary phases, where the stability of the stationary phase can be improved through chemical bonding.

2.2 Physical and Chemical Properties

Solubility: Easily soluble in organic solvents such as toluene, THF, and dichloromethane, but easily hydrolyzed in water.

Stability: Sensitive to moisture and requires storage and reaction under anhydrous conditions.

Thermal stability: The biphenyl structure endows it with high thermal stability, making it suitable for high-temperature chromatographic analysis.

3. Application in chromatographic stationary phase

3.1 As a stationary phase for reverse phase chromatography (RP-HPLC)

Reverse phase chromatography (RP-HPLC) is the most commonly used separation mode, and its stationary phase is usually composed of silica gel modified with hydrophobic groups (such as C18, phenyl). Trichlorosilylphenyl may be used for the following purposes:

Enhanced hydrophobic interactions: The hydrophobicity of biphenyl groups is strong, which may increase their ability to retain non-polar compounds such as polycyclic aromatic hydrocarbons and fat soluble vitamins.

π - π selectivity: The biphenyl structure can undergo π - π interactions with aromatic analytes such as benzene derivatives and drug molecules, improving separation selectivity.

3.2 Separation of Aromatic Compounds

Due to the planar structure of biphenyl groups, this stationary phase may have special selectivity for the following analytes:

Polycyclic aromatic hydrocarbons (PAHs): such as naphthalene, phenanthrene, pyrene, etc.

Drug molecules: such as antibiotics and hormone drugs containing benzene rings.

Environmental pollutants: such as pesticide residues, plasticizers, etc.

3.3 As a precursor for functionalized stationary phases

CAS NO.18030-61-0 p-Trichlorosilylbiphenyl can be further derivatized for the preparation of more complex stationary phases:

Chiral stationary phase: used for enantiomeric separation by introducing chiral groups such as cyclodextrin and cellulose derivatives.

Mixed mode stationary phase: Combining ion exchange groups (such as - SO₃H, - NH ?) to achieve multiple interaction mechanisms.

CAS NO.18030-61-0 p-Trichlorosilylbiphenyl, as a compound with both reactivity and selectivity potential, has important application prospects in the field of chromatographic stationary phases. By optimizing the bonding process, efficient chromatographic columns suitable for complex sample analysis can be developed.

Edited by : Alan Liu
Email : alan.liu@dakenchem.com