2-Butanone oxime is commonly found in alkyd resin coatings or silicone sealants and may pose a carcinogenic risk due to its reclassification as a Class 1B carcinogen.

The researchers developed a method for determining aerosol concentrations of 2-Butanone oxime in workplace air in the range of 1/10 to 2 of the MAC value, i.e., 0.1 mg/m 3 to 2 mg/m 3. The method consists of trapping airborne 2-Butanone oxime aerosols onto a sampler (a glass tube with silica gel) and extracting them with methanol, and using gas chromatography with flame ionization detector. Gas chromatography with a flame ionization detector was used to analyze the resulting solution in the presence of coexisting substances. Validation parameters were determined according to the guidelines of EN 482. The limit of detection at 6.79 ng/ml and the relative total uncertainty of 11.19% was determined. The method can be used by environmental occupational hygiene laboratories to measure concentrations of butan-2-one oxime in the air.

References:

[1] DOBRZY?SKA E, KOWALSKA J. 2-Butanone Oxime, a Chemical of Concern in the Working Environment[J]. Journal of Ecological Engineering, 2024. DOI:10.12911/22998993/175061.