產(chǎn)品概述
Cleaved-Notch1 Rabbit Polyclonal Antibody
Rabbit Polyclonal Antibody
Rabbit
WB,IHC-F,IHC-P,ICC/IF,ELISA
Human,Mouse,Rat
產(chǎn)品性能
Unconjugated
Cleaved
IgG
Polyclonal Antibody
Liquid
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Affinity Purification
免疫原
NOTCH1
NOTCH1; TAN1; Neurogenic locus notch homolog protein 1; Notch 1; hN1; Translocation-associated notch protein TAN-1
4851
P46531
產(chǎn)品應(yīng)用
WB: 1:500-1:1000 IHC: 1:50-1:100 IF: 1:50-1:200 ELISA: 1:10000
Calculated MW: 273 kDa; Observed MW: 110 kDa
研究背景
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting.
研究領(lǐng)域
Neuroscience
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