產(chǎn)品概述
Phospho-BRAF (Thr401) Rabbit Polyclonal Antibody
Rabbit Polyclonal Antibody
Rabbit
WB,ICC/IF,IP
Human,Mouse,Rat
產(chǎn)品性能
Unconjugated
Phosphorylated
IgG
Polyclonal Antibody
Liquid
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Affinity Chromatography
免疫原
BRAF
BRAF; BRAF1; RAFB1; Serine/threonine-protein kinase B-raf; Proto-oncogene B-Raf; p94; v-Raf murine sarcoma viral oncogene homolog B1
673
P15056
產(chǎn)品應(yīng)用
WB: 1:500-1:1000 IF: 1:50-1:200 IP: 1:20
Calculated MW: 84 kDa; Observed MW: 84 kDa
研究背景
Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron. Frequently mutated in thyroid cancers, skin melanomas and at lower frequency in a wide range of human cancers. An activating mutation, mimicking phosphorylation of the activation loop, is seen in 60% of malignant melanoma samples. Raf mutations are generally exclusive to Ras activating mutations.
研究領(lǐng)域
Cell Biology
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