產(chǎn)品概述
產(chǎn)品名稱(Product Name) | JAK1(7G6)Mouse Monoclonal Antibody |
描述(Description) | Mouse Monoclonal Antibody |
宿主(Host) | Mouse |
應(yīng)用(Application) | IHC-P,IF-P,IF-F,ICC/IF |
種屬反應(yīng)性(Reactivity) | Human,Rat,Mouse |
產(chǎn)品性能
偶聯(lián)物(Conjugation) | Unconjugated |
修飾(Modification) | Unmodified |
同種型(Isotype) | IgG |
克?。–lonality) | Monoclonal |
形式(Form) | Liquid |
存放說明(Storage) | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
儲(chǔ)存溶液(Buffer) | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N. |
純化方式(Purification) | Affinity purification |
免疫原
基因名(Gene Name) | JAK1 |
別名(Alternative Names) | JAK1 |
基因ID(Gene ID) | 3716 |
蛋白ID(SwissProt ID) | P23458 |
產(chǎn)品應(yīng)用
稀釋比(Dilution Ratio) | IHC-P 1:100-200, IF-P/IF-F/ICC/IF 1:50-200 |
蛋白分子量(Molecular Weight) | 130kDa |
研究背景
This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta and interferon-gamma signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016],catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,domain:Possesses two phosphotransferase domains. The second one probably contains the catalytic domain (By similarity), while the presence of slight differences suggest a different role for domain 1.,domain:The FERM domain mediates interaction with JAKMIP1.,function:Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.,sequence caution:Translation N-terminally extended.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.,similarity:Contains 1 FERM domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,subcellular location:Wholly intracellular, possibly membrane associated.,subunit:Interacts with IL31RA, JAKMIP1 and SHB.,tissue specificity:Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue.,
研究領(lǐng)域
Jak_STAT;Pathways in cancer;Pancreatic cancer;
關(guān)鍵字: JAK1;JAK1(7G6)Mouse;Monoclonal;Antibody;一抗
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