產(chǎn)品概述
HP1 alpha (1E8) Mouse Monoclonal Antibody
Mouse Monoclonal Antibody
Mouse
WB,IHC-P
Human,Rat,Mouse
產(chǎn)品性能
Unconjugated
Unmodified
IgG1
Monoclonal Antibody
Liquid
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Affinity Purification
免疫原
CBX5
CBX5; HP1A; Chromobox protein homolog 5; Antigen p25; Heterochromatin protein 1 homolog alpha; HP1 alpha
23468
P45973
產(chǎn)品應用
WB: 1:500-1:1000 IHC: 1:50-1:100
Calculated MW: 22 kDa; Observed MW: 22 kDa
研究背景
Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
研究領(lǐng)域
Epigenetics and Nuclear Signaling
武漢恩璣生命科技有限公司
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